Nathan Drummond's AFL debut lasted less than two quarters and dealt him a season-ending knee reconstruction.
After more than a season out, the 20-year-old Richmond midfielder will make his senior comeback in Sunday's match against Hawthorn at the MCG.
Drummond injured his knee in the second quarter of the round-four game last season against Melbourne.
The Tigers also recalled Reece Conca, while Brett Deledio has a calf muscle injury and Connor Menadue was dropped.
The in-form Hawks recalled Tim O'Brien for Angus Litherland.
Charlie Dixon's ankle injury means John Butcher will also play his first AFL match this season.
The Power have made three changes for their must-win home game, with Brad Ebert and Jared Polec also returning.
Jake Neade is listed as ill and Karl Amon was dropped.
The Giants will bring in Nathan Wilson for Jack Steele, who has a fractured hand.
Also this Sunday, Essendon fans will finally see top-10 draft pick Aaron Francis in AFL action.
Francis will make his debut at Etihad Stadium against Brisbane, a clash that should settle who finishes last this season.
The utility was taken at No.6 in last November's draft, one pick behind teammate Darcy Parish - a big positive for Essendon in their difficult season.
The Bombers also brought back Adam Cooney, with James Gwilt (knee) and Craig Bird (rested) the omissions.
Brisbane brought back Daniel Merrett, Liam Dawson and Josh Walker for Ryan Lester, Jarrad Jansen and Daniel McStay (leg).